SIST EN 482:2021

SLOVENSKI STANDARD
SIST EN 482:2021
01-maj-2021
Nadomešča:
SIST EN 482:2012+A1:2016
Izpostavljenost na delovnem mestu - Postopki za določevanje koncentracije
kemičnih agensov - Osnovne zahtevane lastnosti
Workplace exposure - Procedures for the determination of the concentration of chemical
agents - Basic performance requirements
Exposition am Arbeitsplatz - Verfahren zur Bestimmung der Konzentration von
chemischen Arbeitsstoffen - Grundlegende Anforderungen an die Leistungsfähigkeit
Exposition sur les lieux de travail - Procédures pour déterminer la concentration d'agents
chimiques - Exigences élémentaires relatives aux performances
Ta slovenski standard je istoveten z: EN 482:2021
ICS:
13.040.30 Kakovost zraka na delovnem Workplace atmospheres
mestu
SIST EN 482:2021 en,fr,de
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.

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SIST EN 482:2021

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SIST EN 482:2021


EN 482
EUROPEAN STANDARD

NORME EUROPÉENNE

March 2021
EUROPÄISCHE NORM
ICS 13.040.30 Supersedes EN 482:2012+A1:2015
English Version

Workplace exposure - Procedures for the determination of
the concentration of chemical agents - Basic performance
requirements
Exposition sur les lieux de travail - Procédures pour Exposition am Arbeitsplatz - Verfahren zur
déterminer la concentration d'agents chimiques - Bestimmung der Konzentration von chemischen
Exigences élémentaires relatives aux performances Arbeitsstoffen - Grundlegende Anforderungen an die
Leistungsfähigkeit
This European Standard was approved by CEN on 8 February 2021.

CEN members are bound to comply with the CEN/CENELEC Internal Regulations which stipulate the conditions for giving this
European Standard the status of a national standard without any alteration. Up-to-date lists and bibliographical references
concerning such national standards may be obtained on application to the CEN-CENELEC Management Centre or to any CEN
member.

This European Standard exists in three official versions (English, French, German). A version in any other language made by
translation under the responsibility of a CEN member into its own language and notified to the CEN-CENELEC Management
Centre has the same status as the official versions.

CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway,
Poland, Portugal, Republic of North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and
United Kingdom.





EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION

EUROPÄISCHES KOMITEE FÜR NORMUNG

CEN-CENELEC Management Centre: Rue de la Science 23, B-1040 Brussels
© 2021 CEN All rights of exploitation in any form and by any means reserved Ref. No. EN 482:2021 E
worldwide for CEN national Members.

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SIST EN 482:2021
EN 482:2021 (E)
Contents                                                             Page
European foreword . 3
Introduction . 4
1 Scope . 5
2 Normative references . 5
3 Terms and definitions . 6
4 Classification . 6
4.1 General . 6
4.2 Screening measurements of time-weighted average concentration . 6
4.3 Screening measurements of variation of concentration in time and/or space . 6
4.4 Measurements for comparison with OELVs . 6
4.5 Periodic measurements . 6
5 Performance requirements . 7
5.1 General . 7
5.2 Screening measurements of time-weighted average concentration . 7
5.3 Screening measurements of variation of concentration in time and/or space . 7
5.4 Measurements for comparison with limit values and periodic measurements . 7
5.4.1 General . 7
5.4.2 Unambiguity . 7
5.4.3 Selectivity . 7
5.4.4 Averaging time . 8
5.4.5 Measuring range . 8
5.4.6 Expanded uncertainty . 8
5.4.7 Chemical agents where compliant methods are not available . 9
5.5 Composite procedures . 9
5.6 Transport, handling and/or storage . 9
5.7 Environmental conditions . 9
5.8 Description of measuring procedure . 9
5.9 Dimension of result . 9
5.10 Additional requirements . 10
6 Test method and calculation of uncertainty of measurement . 11
7 Validation report . 12
Annex A (informative) Structure of a method description. 13
Annex B (informative) Calculation of uncertainty of measurement. 14
Bibliography . 22


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SIST EN 482:2021
EN 482:2021 (E)
European foreword
This document (EN 482:2021) has been prepared by Technical Committee CEN/TC 137 “Assessment of
workplace exposure to chemical and biological agents”, the secretariat of which is held by DIN.
This document corresponds to ISO 20581:2016, published by the International Organization for
Standardization (ISO) which contains a modified version of EN 482:2012+A1:2015.
This European Standard shall be given the status of a national standard, either by publication of an
identical text or by endorsement, at the latest by September 2021, and conflicting national standards
shall be withdrawn at the latest by September 2021.
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. CEN shall not be held responsible for identifying any or all such patent rights.
This document supersedes EN 482:2012+A1:2015.
The major technical changes between this document and the previous edition are as follows:
a) standard title adapted to the wording used in the scope;
b) 4.4, which comprised two subclauses, was revised;
c) recommendation regarding exposure peaks inserted in 5.4.4;
d) 5.4.7 reformulated to improve comprehensibility;
e) new Table 2 with additional requirements for the testing parameters added to 5.10;
f) Annex A specified more in detail;
g) new subclause B.9 for blank subtraction added.
According to the CEN-CENELEC Internal Regulations, the national standards organisations of the
following countries are bound to implement this European Standard: Austria, Belgium, Bulgaria,
Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland,
Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Republic of
North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and the
United Kingdom.
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SIST EN 482:2021
EN 482:2021 (E)
Introduction
National laws and regulations require the assessment of the exposure of a worker to chemical agents in
workplace atmospheres. One way of assessing such exposure is to measure the concentration of a
chemical agent in the air in the worker's breathing zone. The procedures used for such measurements
should provide reliable and valid results for the comparison purpose of exposure measurements with
occupational exposure limit values (OELVs) and for the provision of acceptable control strategies.
This document introduces basic requirements to fulfil the measurement procedures in the process of
quantitative exposure assessment. Specific European Standards and International Standards have been
prepared for different types of measuring procedures and measuring devices. These include standards
for airborne particle samplers (EN 13205, all parts), diffusive samplers (EN 838 and ISO 16107),
pumped samplers (EN ISO 22065), short-term detector tubes (EN ISO 17621), personal sampling
pumps (EN ISO 13137), metals and metalloids in airborne particles (EN ISO 21832), mixtures of
airborne particles and vapour (EN 13936) and direct-reading instruments for toxic gases and vapours
(EN 45544, all parts). In these specific documents, additional requirements have been included for the
procedure or device in question, so that the basic requirements of this document are not compromised.
Where no specific European Standard and/or International Standard exist, only the basic requirements
apply.
Performance requirements given in this document are intended to apply under environmental
conditions present at the workplace. However, because a wide range of environmental conditions are
encountered in practice, this document specifies requirements that have to be fulfilled by measuring
procedures when tested under prescribed laboratory conditions.
It is the user's responsibility to choose the appropriate procedures or devices that meet the
requirements of this document. One way of doing this is to obtain information or confirmation from the
provider of a procedure or the manufacturer of a device. Type-testing or, more generally, assessment of
the performance of procedures or devices, can be undertaken by the manufacturer, user, testing house
or research and development laboratory, as is most appropriate. A number of existing procedures for
workplace measurements have either been tested over a part of the required minimum measuring
range, but not over the entire range, or have not been tested for all environmental influences and
potential interferences. If these partially validated procedures meet the performance requirements of
this document, they can be used at present. Nevertheless, these procedures should be tested over the
full ranges as soon as is reasonably practicable.
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SIST EN 482:2021
EN 482:2021 (E)
1 Scope
This document specifies basic performance requirements for procedures for the determination of the
concentration of chemical agents in workplace atmospheres as required by the Chemical Agents
Directive 98/24/EC [13]. These requirements apply to all steps of measuring procedures regardless of
the physical form of the chemical agent (gas, vapour, airborne particles), measuring procedures with
separate sampling and analytical methods, and direct-reading instruments.
This document specifies requirements that are fulfilled by measuring procedures when tested under
prescribed laboratory conditions due to a wide range of environmental conditions encountered in
practice.
2 Normative references
The following documents are referred to in the text in such a way that some or all of their content
constitutes requirements of this document. For dated references, only the edition cited applies. For
undated references, the latest edition of the referenced document (including any amendments) applies.
EN 481, Workplace atmospheres - Size fraction definitions for measurement of airborne particles
EN 838, Workplace exposure - Procedures for measuring gases and vapours using diffusive samplers -
Requirements and test methods
EN 1540, Workplace exposure - Terminology
EN 13205 (all parts), Workplace exposure - Assessment of sampler performance for measurement of
airborne particle concentrations
EN 13936, Workplace exposure - Procedures for measuring a chemical agent present as a mixture of
airborne particles and vapour - Requirements and test methods
EN 45544 (all parts), Workplace atmospheres - Electrical apparatus used for the direct detection and
direct concentration measurement of toxic gases and vapours
EN ISO 13137, Workplace atmospheres - Pumps for personal sampling of chemical and biological agents -
Requirements and test methods (ISO 13137)
EN ISO 17621, Workplace atmospheres - Short term detector tube measurement systems - Requirements
and test methods (ISO 17621)
EN ISO 21832, Workplace air - Metals and metalloids in airborne particles - Requirements for evaluation
of measuring procedures (ISO 21832)
EN ISO 22065, Workplace air - Gases and vapours - Requirements for evaluation of measuring procedures
using pumped samplers (ISO 22065)
ISO 78-2, Chemistry - Layouts for standards — Part 2: Methods of chemical analysis
ISO 16107, Workplace atmospheres - Protocol for evaluating the performance of diffusive samplers
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EN 482:2021 (E)
3 Terms and definitions
For the purposes of this document, the terms and definitions given in EN 1540 apply.
ISO and IEC maintain terminological databases for use in standardization at the following addresses:
— IEC Electropedia: available at http://www.electropedia.org/
— ISO Online browsing platform: available at https://www.iso.org/obp
4 Classification
4.1 General
In this document, measurements are classified according to their purposes. These classifications are
based upon the measurement strategy in EN 689.
4.2 Screening measurements of time-weighted average concentration
Screening measurements of time-weighted average concentration are performed to obtain
semiquantitative information on exposure levels. Such information is used to identify potential health
hazards, and to estimate the risk to health based on the likely severity of harm and the probability of its
occurrence. These measurements can also determine if the exposure is significantly below or above the
OELV. Apparatus intended for detection and concentration measurements of chemical agents, that meet
the requirements of this document and is capable of reporting the time weighted average, can be used.
4.3 Screening measurements of variation of concentration in time and/or space
Screening measurements of variation of concentration in time and/or space are used to provide
information on the likely pattern of the concentration of chemical agents in the air and to identify
locations and periods of elevated exposure. The screening measurements also provide information on
the location and intensity of emission sources and to estimate the effectiveness of ventilation or other
technical measures. Apparatus intended for detection and concentration measurements of chemical
agents, that meet the requirements of this document, can be used.
4.4 Measurements for comparison with OELVs
Provided the method meets established acceptable uncertainty criteria, measurements can be made for
comparison with OELVs. Measurements can be taken to determine whether a worker’s exposure
exceeds the OELV initially and repeated after any significant change in working conditions, industrial
process, products or chemicals or OELV.
4.5 Periodic measurements
Periodic measurements are used to determine whether exposure conditions have changed since the
measurements for comparison with OELVs were performed, or whether control measures remain
effective. The interval between measurements should be established based on the initial occupational
exposure assessment or subsequent amendments to it.
NOTE Since the composition of the workplace atmosphere will have been investigated during the initial
occupational exposure assessment and the composition is known not to vary over time, it can be appropriate for
periodic measurements to use procedures with lower selectivity.
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EN 482:2021 (E)
5 Performance requirements
5.1 General
Performance requirements for measuring procedures depend on the purpose for which they are used.
The performance requirements for screening measurements are less stringent than for measurements
for the comparison with limit values and periodic measurements. Therefore, the performance
requirements for screening measurements in 5.2 and 5.3 are only given in general terms.
5.2 Screening measurements of time-weighted average concentration
The purpose of these measurements is described in 4.2. The measuring procedures shall include the
following:
a) adequate selectivity for the chemical agent;
b) averaging time less than or equal to the limit value reference period;
c) measuring range that includes the limit value; and
d) expanded uncertainty that is fit for purpose.
5.3 Screening measurements of variation of concentration in time and/or space
The purpose of these measurements is described in 4.3. The measuring procedures shall include the
following:
a) adequate selectivity for the chemical agent;
b) short averaging time (for variation of concentration in time ≤ 5 min; for variation of concentration
in space ≤ 15 min);
c) measuring range that is fit for purpose; and
d) expanded uncertainty that is fit for purpose.
5.4 Measurements for comparison with limit values and periodic measurements
5.4.1 General
A measuring procedure for a given limit value which meets the requirements given in 5.4.2 to 5.4.6 is
called compliant method.
5.4.2 Unambiguity
A measuring procedure shall produce an unambiguous result for the concentration of the chemical
agent being measured in the specified measuring range, i.e. an analytically determined value shall
correspond to one concentration only within a known uncertainty.
5.4.3 Selectivity
The measuring procedure shall contain appropriate information about the nature and magnitude of any
interference.


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EN 482:2021 (E)
Requirements on selectivity vary from case to case, depending on what is known in advance about the
workplace air. If the identity of all contaminants present is not known in advance then the measuring
procedure shall have a high selectivity. If the identity of all contaminants is known prior to
measurement and there are no interferents present, then a measuring procedure with a low selectivity
can be used.
Where a particle size fraction, as defined in EN 481, is specified for an OELV, procedures for measuring
chemical agents present as airborne particles shall prescribe a method for sampling the specified
particle size fraction.
NOTE In addition to samplers meeting the requirements of EN 481, there are samplers which themselves
define the sample (see EN 13205 series).
If different limit values are set for different species of a chemical agent, then the measuring procedure
shall determine the individual species concerned.
5.4.4 Averaging time
The averaging time is equal to the sampling time, which shall be less than or equal to the limit value
reference period. Depending on the sampling techniques, the sampling time can vary.
NOTE A full shift average concentration, typically the 8 h time-weighted concentration, gives a representative
description of the occupational exposure situation.
Exposure peaks that can occur systematically or randomly during the shift should fulfil the short-term
exposure limit conditions (see 5.4.6), if any.
5.4.5 Measuring range
The measuring range of the procedure listed in Table 1 shall cover at least the concentrations from
0,1 times to 2 times the limit value for long-term measurements, and from 0,5 times to 2 times the limit
value for short-term measurements.
NOTE Reference [9] provides a list of International limit values for chemical agents (Occupational exposure
limits, OELs).
5.4.6 Expanded uncertainty
The requirements for expanded uncertainty are given in Table 1.
Table 1 — Expanded uncertainty requirements for measurements for comparison with limit
values and periodic measurements
Reference period Measuring range Relative Relative expanded
expanded uncertainty
uncertainty (mixtures of airborne
particles and vapour)
short-term 0,5 times to 2 times limit ≤ 50 % ≤ 50 %
(for example, value
15 min)
long-term 0,1 times to < 0,5 times ≤ 50 % ≤ 50 %
limit value
long-term 0,5 times to 2 times limit ≤ 30 % ≤ 50 %
value
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EN 482:2021 (E)
NOTE Variation of exposure to chemical agents in the workplace can be significantly greater than indicated
by the uncertainty of a single measurement calculated according to this document. This is due to the temporal and
spatial variability of workplace exposure.
5.4.7 Chemical agents where compliant methods are not available
Limit values are determined by authorities independently from those developing measuring
procedures. If a measuring procedure is not available for a given limit value which meets the
requirements given in 5.4.5 and 5.4.6 a measuring procedure should be used whose performance is
closest to the requirements. The method employed should clearly state its limitations when measuring
at the exposure limit.
5.5 Composite procedures
The performance requirements detailed in 5.2, 5.3 and 5.4 shall be fulfilled for the whole measuring
procedure even if the measuring procedure consists of several distinct steps, for example, preparation
of equipment, sampling, transport and storage, sample preparation and analysis. Each step of the
measuring procedure may be tested individually and can be combined as a whole.
5.6 Transport, handling and/or storage
Transport, handling and/or storage of samples, if appropriate, shall be carried out in such a way that
the physical and chemical integrity is maintained between sampling and analysis.
5.7 Environmental conditions
The effect of environmental conditions (for example, temperature, humidity, atmospheric pressure,
and/or air speed) on the performance of the method shall be tested in the laboratory. Performance
requirements concerning unambiguity, selectivity, expanded uncertainty, minimum measuring range
and averaging time shall be fulfilled under the conditions likely to be encountered in the workplace.
NOTE Due to the time, cost, and effort involved, it is not practicable to carry out a comprehensive evaluation
of environmental influences in the field and therefore laboratory tests are specified in this document. However,
field tests can provide valuable information on the performance of measurement methods (for example,
interferences from nearby workplaces).
The range of environmental conditions under which the performance requirements of 5.2 to 5.5 are
fulfilled shall be specified in the measuring procedure.
5.8 Description of measuring procedure
The measuring procedure shall be documented in accordance with ISO 78-2. Any clause or subclause
which is unnecessary in a particular case may be omitted, and others, if required, may be added in the
most appropriate places. The description shall contain all necessary information to perform the
measuring procedure, including information about the attainable expanded uncertainty, measuring
range, averaging time, interferences and environmental or other conditions that can influence the
performance of the measuring procedure.
If correction factors are applied, for example, for a known and explainable bias due to environmental
influences, these shall be justified in the measuring procedure.
NOTE An example for the structure of a method description based on ISO 78-2 is given in Annex A.
5.9 Dimension of result
The final measurement result shall be expressed in the same units as those of the limit value. This can
be achieved directly or by means of a suitable conversion.
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EN 482:2021 (E)
This requirement is not obligatory for screening measurements of the variation of concentration in time
and/or space.
5.10 Additional requirements
In addition to the requirements given in 5.2 to 5.9, further requirements specified in EN 838,
EN 13205 (all parts), EN 13936, EN 45544 (all parts), EN ISO 13137, EN ISO 17621, EN ISO 21832,
EN ISO 22065 and ISO 16107 shall be met for particular types of measuring procedures and devices, as
appropriate.
Table 2 lists additional requirements of testing parameters.
Table 2 — Additional requirements of testing parameters
Standard Required testing parameters
EN 838 Quantification limit of the measuring procedure, analytical recovery,
nominal uptake rate, air velocity/sampler orientation, sampler leak test,
shelf life, and marking.
EN 13205 (all parts) Specimen variability, pump design safety and electrical safety, and sampler
evaluation.
EN 13936 Comply with the requirements of this document, EN 13205 (all parts),
EN ISO 13137, EN ISO 21832 and EN ISO 22065.
EN 45544 (all parts) Instrument vibration and drop test, measurement of deviations, alarm
system including audible alarm, set point(s), and response time, flow failure
warning, warm-up time, time of response and recovery, addition of
sampling probe, field verification kit, gas concentrations above the
measuring range, electrical fault signal, extended operation under standard
test gas, orientation, electrical tests including battery capacity, mains power
supply, time weighted average function, and electromagnetic compatibility,
and instrument drift tests.
EN ISO 13137 Features and mass of pumps, design safety, operating time, start-up and
long-term performance, short-term interruption of air flow, mechanical
strength, timer accuracy, electromagnetic compatibility, explosion hazard,
charger, and marking.
EN ISO 17621 Scale, packing of the tubes, interferences, overloading, evaluation of stain,
shelf life, marking and mechanical strength for detector tubes; Explosion
hazard, stroke volume, leakage, and mechanical strength and durability for
detector tube pumps.
EN ISO 21832 Sampler evaluation, detection limit (LOD) and quantification limit (LOQ) of
the measuring procedure, analytical recovery, and interferences.
EN ISO 22065 Quantification limit of the measuring procedure, analytical recovery,
sampler leak test, shelf life, marking, flow resistance, and sampler
breakthrough test.
ISO 16107 Bias relative to manufacturer-specified sampling rate, variation in sampling
rate (for example, from poor sampler dimension tolerance), effects of wind,
temperature, humidity, target concentration itself, and diffusive loss from
sampler.
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SIST EN 482:2021
EN 482:2021 (E)
6 Test method and calculation of uncertainty of measurement
6.1 Estimate the expanded uncertainty of results obta
...