EN ISO 10298:2020

SLOVENSKI STANDARD
01-december-2020
Plinske jeklenke - Plini in zmesi plinov - Določanje strupenosti za izbiro izhodnega
priključka ventila na jeklenki (ISO 10298:2018)
Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of
cylinder valve outlets (ISO 10298:2018)
Gasflaschen - Gase und Gasgemische - Bestimmung der Toxizität zur Auswahl von
Ventilausgängen (ISO 10298:2018)
Bouteilles à gaz - Gaz et mélanges de gaz - Détermination de la toxicité pour le choix
des raccords de sortie de robinets (ISO 10298:2018)
Ta slovenski standard je istoveten z: EN ISO 10298:2020
ICS:
23.020.35 Plinske jeklenke Gas cylinders
71.100.20 Industrijski plini Gases for industrial
application
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.

EN ISO 10298
EUROPEAN STANDARD
NORME EUROPÉENNE
October 2020
EUROPÄISCHE NORM
ICS 71.100.20
English Version
Gas cylinders - Gases and gas mixtures - Determination of
toxicity for the selection of cylinder valve outlets (ISO
10298:2018)
Bouteilles à gaz - Gaz et mélanges de gaz - Gasflaschen - Gase und Gasgemische - Bestimmung der
Détermination de la toxicité pour le choix des raccords Toxizität zur Auswahl von Ventilausgängen (ISO
de sortie de robinets (ISO 10298:2018) 10298:2018)
This European Standard was approved by CEN on 28 September 2020.

CEN members are bound to comply with the CEN/CENELEC Internal Regulations which stipulate the conditions for giving this
European Standard the status of a national standard without any alteration. Up-to-date lists and bibliographical references
concerning such national standards may be obtained on application to the CEN-CENELEC Management Centre or to any CEN
member.
This European Standard exists in three official versions (English, French, German). A version in any other language made by
translation under the responsibility of a CEN member into its own language and notified to the CEN-CENELEC Management
Centre has the same status as the official versions.

CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway,
Poland, Portugal, Republic of North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and
United Kingdom.
EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION

EUROPÄISCHES KOMITEE FÜR NORMUNG

CEN-CENELEC Management Centre: Rue de la Science 23, B-1040 Brussels
© 2020 CEN All rights of exploitation in any form and by any means reserved Ref. No. EN ISO 10298:2020 E
worldwide for CEN national Members.

Contents Page
European foreword . 3

European foreword
The text of ISO 10298:2018 has been prepared by Technical Committee ISO/TC 58 "Gas cylinders” of
the International Organization for Standardization (ISO) and has been taken over as EN ISO 10298:2020
by Technical Committee CEN/TC 23 “Transportable gas cylinders” the secretariat of which is held by
BSI.
This European Standard shall be given the status of a national standard, either by publication of an
identical text or by endorsement, at the latest by April 2021, and conflicting national standards shall be
withdrawn at the latest by April 2021.
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. CEN shall not be held responsible for identifying any or all such patent rights.
According to the CEN-CENELEC Internal Regulations, the national standards organizations of the
following countries are bound to implement this European Standard: Austria, Belgium, Bulgaria,
Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland,
Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Republic of
North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and the
United Kingdom.
Endorsement notice
The text of ISO 10298:2018 has been approved by CEN as EN ISO 10298:2020 without any modification.

INTERNATIONAL ISO
STANDARD 10298
Third edition
2018-02
Gas cylinders — Gases and gas
mixtures — Determination of toxicity
for the selection of cylinder valve
outlets
Bouteilles à gaz — Gaz et mélanges de gaz — Détermination de la
toxicité pour le choix des raccords de sortie de robinets
Reference number
ISO 10298:2018(E)
©
ISO 2018
ISO 10298:2018(E)
© ISO 2018
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting
on the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address
below or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: +41 22 749 01 11
Fax: +41 22 749 09 47
Email: copyright@iso.org
Website: www.iso.org
Published in Switzerland
ii © ISO 2018 – All rights reserved

ISO 10298:2018(E)
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Determination of toxicity . 2
4.1 General . 2
4.2 Test method . 2
4.2.1 Test procedure . 2
4.2.2 Results for pure gases . . 2
4.3 Calculation method . 2
Annex A (informative) Selection of an LC value for a particular gas . 4
Annex B (informative) LC50 values for toxic gases and toxic vapours used in gas mixtures .7
Bibliography .12
ISO 10298:2018(E)
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
bodies (ISO member bodies). The work of preparing International Standards is normally carried out
through ISO technical committees. Each member body interested in a subject for which a technical
committee has been established has the right to be represented on that committee. International
organizations, governmental and non-governmental, in liaison with ISO, also take part in the work.
ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters of
electrotechnical standardization.
The procedures used to develop this document and those intended for its further maintenance are
described in the ISO/IEC Directives, Part 1. In particular the different approval criteria needed for the
different types of ISO documents should be noted. This document was drafted in accordance with the
editorial rules of the ISO/IEC Directives, Part 2 (see www .iso .org/ directives).
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. ISO shall not be held responsible for identifying any or all such patent rights. Details of
any patent rights identified during the development of the document will be in the Introduction and/or
on the ISO list of patent declarations received (see www .iso .org/ patents).
Any trade name used in this document is information given for the convenience of users and does not
constitute an endorsement.
For an explanation on the voluntary nature of standards, the meaning of ISO specific terms and
expressions related to conformity assessment, as well as information about ISO's adherence to the
World Trade Organization (WTO) principles in the Technical Barriers to Trade (TBT) see the following
URL: www .iso .org/ iso/ foreword .html.
This document was prepared by ISO/TC 58 Gas cylinders, SC 2, Cylinder fittings.
This third edition cancels and replaces the second edition (ISO 10298:2010), which has been technically
revised.
The main changes compared to the previous edition are as follows:
— The Scope and Clause 4 have been clarified.
— The terms and definitions in Clause 3 have been changed and, in particular, the reference to FTSC
codes (that were in ISO 5145) was changed to ISO 14456.
— Some LC50 values have been updated.
iv © ISO 2018 – All rights reserved

ISO 10298:2018(E)
Introduction
ISO 5145 specifies the dimensions of different valve outlets for different compatible gas groups. These
compatible gas groups are determined according to practical criteria defined in ISO 14456.
These criteria are based on certain physical, chemical, toxic and corrosive properties of the gases. In
particular, the tissue corrosiveness is considered in this document.
The aim of this document is to assign for each gas a classification category that takes into account the
toxicity by inhalation of the gas. For gas mixtures containing toxic components a calculation based on
the method specified in the GHS is proposed.
Since the publication of the first edition of ISO 10298, this International Standard has been used for other
purposes than the selection of cylinder valve outlets, e.g. providing toxicity data for the classification
of gas and gas mixtures according to the international transport regulations and according to the
classification of dangerous substances regulations, which since 2003 is under the umbrella of the
Globally Harmonized System (GHS).
INTERNATIONAL STANDARD ISO 10298:2018(E)
Gas cylinders — Gases and gas mixtures — Determination
of toxicity for the selection of cylinder valve outlets
1 Scope
This document lists the best available acute-toxicity data of gases taken from a search of the current
literature to allow the classification of gases and gas mixtures for toxicity by inhalation.
2 Normative references
There are no normative references in this document.
3 Terms and definitions
For the purpose of this document, the following terms and definitions apply.
ISO and IEC maintain terminological databases for use in standardization at the following addresses:
— ISO Online Browsing platform: available at http:// www .iso .org/ obp
— IEC Electropedia: available at http:// www .electropedia .org/
3.1
lethal concentration 50
LC
concentration of a substance in air exposure to which, for a specified length of time, it is expected to
cause the death of 50 % of the entire defined experimental animal population after a defined time period
Note 1 to entry: See Annex A for the selection of this LC value.
3.2
toxicity level
level of toxicity of gases and gas mixtures
Note 1 to entry: In ISO 14456, the toxicity level is divided into three groups:
—  Subdivision 1: non toxic [LC > 5 000 ppm (volume fraction)]
—  Subdivision 2: toxic [200 ppm (volume fraction) < LC ≤ 5 000 ppm (volume fraction)]
—  Subdivision 3: very toxic [LC ≤ 200 ppm (volume fraction)]
These subdivisions are sometimes used in transport regulations.
where
LC values correspond to 1 h exposure to gas;
ppm (volume fraction) indicates parts per million, by volume.
Note 2 to entry: In the GHS, the inhalation toxicity levels are:
ISO 10298:2018(E)
Category 1: Fatal if inhaled 0 ppm < LC ≤ 100 ppm (volume fraction)
Category 2:
...