ISO 10298:2018/Amd 1:2021

Overview

ISO 10298:2018/Amd 1:2021 is an important amendment to the international standard governing gas cylinders and their safety features. This update focuses specifically on the determination of toxicity for the selection of cylinder valve outlets used with gases and gas mixtures. Developed by ISO Technical Committee ISO/TC 58 and Subcommittee SC 2, it ensures that users and manufacturers properly evaluate toxic risks when choosing valve outlet connections on gas cylinders.

The amendment refines the methodology for assessing toxicity by introducing a revised formula to calculate lethal concentration levels (LC50) for toxic gas components in mixtures. This update is critical for improving safety protocols in the handling, storage, and application of compressed gases, especially where toxicity poses significant risks.

Key Topics

• Toxicity Determination: Enhances the accuracy of toxicity evaluation for gases and mixtures by updating the formula for lethal concentration (LC50) calculations.
• Cylinder Valve Outlet Selection: Provides guidelines to select appropriate valve outlets based on specific toxicity profiles of gases to prevent exposure and contamination.
• Safety in Gas Handling: Supports risk mitigation strategies by integrating toxicity data into cylinder valve design and use.
• Updated Calculation Formula: The amendment introduces a revised equation relating mole fractions of toxic compounds to their LC50 values to better predict the overall toxicity of gas mixtures.
• Standard Compliance: Aligns with ISO’s directives and international safety regulations to ensure consistent global practices in gas cylinder standards.
• Intellectual Property and Copyright: The document details protections and permissions related to the publication and use of the standard.

Applications

ISO 10298:2018/Amd 1:2021 is highly relevant for industries and sectors where compressed gases are routinely used and stored. Key applications include:

• Industrial Gas Production and Distribution: Ensures the safety of valves used on cylinders containing various industrial gases, particularly those with toxic compounds.
• Healthcare and Medical Gases: Assists in selecting valve outlets for medical oxygen and anesthetic gases to minimize risks associated with toxic impurities or mixtures.
• Laboratory and Research Environments: Supports safe handling of specialty gas mixtures used in experiments and testing that involve potentially harmful components.
• Fire Safety and Emergency Services: Enables emergency responders to identify safe cylinder valve types to prevent accidental toxic gas release during crisis situations.
• Manufacturing and Engineering: Guides manufacturers in designing valve outlets compatible with toxic gas mixtures to comply with international safety requirements.
• Transport and Storage: Helps logistics companies and storage facilities select proper cylinder valve configurations to ensure safe transportation and storage of toxic gas cylinders.

Related Standards

To maintain comprehensive safety and interoperability, ISO 10298:2018/Amd 1:2021 works in conjunction with other international standards, including but not limited to:

• ISO 11119 - Gas cylinders made of composite materials
• ISO 4706 - Gas cylinders - Cylinder valves - Specification and type testing
• ISO 14159 - Safety of machinery - Hygiene requirements
• ISO/IEC Directives - Guidelines on the development and updating of standards
• IEC Standards - Related to electrotechnical safety for gas handling equipment

These references help create a robust framework that supports safe, reliable, and standardized gas cylinder usage worldwide.

By implementing the amendments defined in ISO 10298:2018/Amd 1:2021, organizations can enhance safety, reduce toxic exposure risks, and ensure compliance with global best practices for gas cylinder valve outlet selection. This contributes to safer environments across industries reliant on compressed gases and upholds international standardization efforts.