ISO/CIE 28077:2024

International
Standard
ISO/CIE 28077
Third edition
Photocarcinogenesis action
2024-10
spectrum (non-melanoma skin
cancers)
Spectre d'action de la photocarcinogenèse (cancers de la peau
hors mélanome)
Reference number
© ISO/CIE 2024
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© ISO/CIE 2024 – All rights reserved
ii
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms, definitions, symbols and abbreviations . 1
3.1 Terms and definitions .1
3.2 Symbols and abbreviations .1
4 Action spectrum for photocarcinogenesis of non-melanoma skin cancers . 2
5 Tabulated and graphic values . 2
Annex A (informative) Historical background . 7
Bibliography . 8

© ISO/CIE 2024 – All rights reserved
iii
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
bodies (ISO member bodies). The work of preparing International Standards is normally carried out through
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in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the different types
of ISO document should be noted. This document was drafted in accordance with the editorial rules of the
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This document was prepared by the International Commission on Illumination (CIE) Technical Committee
6-32, Action Spectrum for Photocarcinogenesis, in cooperation with Technical Committee ISO/TC 274, Light
and lighting.
This third edition cancels and replaces the second edition (ISO/CIE 28077:2016), which has been technically
revised.
The main changes are as follows:
— text giving historical background shifted to Annex A;
— Normative reference updated;
— Bibliography updated;
— minor editorial changes.
Any feedback or questions on this document should be directed to the user’s national standards body. A
complete listing of these bodies can be found at www.iso.org/members.html.

© ISO/CIE 2024 – All rights reserved
iv
Introduction
Solar ultraviolet radiation (UVR) is recognized as a major cause of non-melanoma skin cancer in humans.
Skin cancer occurs most frequently in the areas of the body most exposed to solar radiation, and correlates
with the duration and intensity of outdoor exposure to UVR. Describing the relationship of exposure
(dose) to risk (skin cancer) requires the availability of a spectral weighting function or action spectrum
for photocarcinogenesis. This document proposes the adoption of an action spectrum derived from
experimental laboratory data and modified to estimate the non-melanoma tumour response in human skin.
The experimental data are not sufficient for specifying effectiveness above 400 nm, but are sufficient for
estimating effectiveness from 400 nm down to 250 nm.

© ISO/CIE 2024 – All rights reserved
v
International Standard ISO/CIE 28077:2024(en)
Photocarcinogenesis action spectrum (non-melanoma skin
cancers)
1 Scope
This document specifies the action spectrum for photocarcinogenesis of non-melanoma skin cancers.
2 Normative references
The following documents are referred to in the text in such a way that some or all of their content constitutes
requirements of this document. For dated references, only the edition cited applies. For undated references,
the latest edition of the referenced document (including any amendments) applies.
CIE S 017/E, ILV: International Lighting Vocabulary
3 Terms, definitions, symbols and abbreviations
3.1 Terms and definitions
For the purposes of this document, the following terms and definitions given in CIE S 017 and the following apply.
ISO and IEC maintain terminology databases for use in standardization at the following addresses:
— ISO Online browsing platform: available at https:// www .iso .org/ obp
— IEC Electropedia: available at https:// www .electropedia .org/
CIE maintains a terminology database for use in standardization at the following address:
— ILV: International Lighting Vocabulary: available at http:// cie .co .at/ e -ilv
3.1.1
ultraviolet radiation
UV radiation
UVR
optical radiation for which the wavelengths are shorter than those for visible radiation
Note 1 to entry: The range between 100 nm and 400 nm is commonly subdivided into: UV-A: 315 nm to 400 nm; UV-B:
280 nm to 315 nm; UV-C: 100 nm to 280 nm.
[SOURCE: CIE S 017/E:2020, entry 17-21-008, modified — Notes 2 to 5 have been omitted.]
3.2 Symbols and abbreviations
[1]
SCUP Skin Cancer Utrecht-Philadelphia (an action spectrum proposed in Reference )
SCUP-m original SCUP action spectrum, based entirely on mouse data
SCUP-h proposed action spectrum estimated by correcting for differences in UV
transmissions between human and murine epidermis
UV-A1 wavelength range from 340 nm to 400 nm

© ISO/CIE 2024 – All rights reserved
UV-A2 wavelength range from 315 nm to 340 nm
4 Action spectrum for photocarcinogenesis of non-melanoma skin cancers
The action spectrum for photocarcinogenesis is based principally on experimental data from mice because
comparable data are not available from humans. The limits of this extrapolation are yet to be determined.
Based on all these considerations, a standard action spectrum for photocarcinogenesis is provided in Table 1
and shown in Figure 1.
Some historic background information on the development of the photocarcinogenesis action spectrum is
given in Annex A.
5 Tabulated and graphic values
Table 1 — Action spectrum for photocarcinogenesis (non-melanoma skin cancer)
Wavelength
Effectiveness (decimal) Effectiveness (exponential)
λ/nm
250 0,010 900 1,090 00E-02
251 0,011 139 1,113 90E-02
252 0,011 383 1,138 30E-02
253 0,011 633 1,163 30E-02
254 0,011 888 1,188 80E-02
255 0,012 158 1,215 80E-02
256 0,012 435 1,243 50E-02
257 0,012 718 1,271 80E-02
258 0,013 007 1,300 70E-02
259 0,013 303 1,330 30E-02
260 0,013 605 1,360 50E-02
261 0,013 915 1,391 50E-02
262 0,014 231 1,423 10E-02
263 0,014 555 1,455 50E-02
264 0,014 886 1,488 60E-02
265 0,015 225 1,522 50E-02
266 0,015 571 1,557 10E-02
267 0,015 925 1,592 50E-02
268 0,016 287 1,628 70E-02
269 0,016 658 1,665 80E-02
270 0,017 037 1,703 70E-02
271 0,017 424 1,742 40E-02
272 0,017 821 1,782 10E-02
273 0,018 226 1,822 60E-02
...