EN ISO 10991:2023

SLOVENSKI STANDARD
01-december-2023
Mikrofluidika - Slovar (ISO 10991:2023)
Microfluidics - Vocabulary (ISO 10991:2023)
Mikrofluidik - Begriffe (ISO 10991:2023)
Microfluidique - Vocabulaire (ISO 10991:2023)
Ta slovenski standard je istoveten z: EN ISO 10991:2023
ICS:
01.040.71 Kemijska tehnologija Chemical technology
(Slovarji) (Vocabularies)
71.020 Proizvodnja v kemijski Production in the chemical
industriji industry
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.

EN ISO 10991
EUROPEAN STANDARD
NORME EUROPÉENNE
September 2023
EUROPÄISCHE NORM
ICS 01.040.71; 71.040.10 Supersedes EN ISO 10991:2009
English Version
Microfluidics - Vocabulary (ISO 10991:2023)
Microfluidique - Vocabulaire (ISO 10991:2023) Mikrofluidik - Begriffe (ISO 10991:2023)
This European Standard was approved by CEN on 19 August 2023.

CEN members are bound to comply with the CEN/CENELEC Internal Regulations which stipulate the conditions for giving this
European Standard the status of a national standard without any alteration. Up-to-date lists and bibliographical references
concerning such national standards may be obtained on application to the CEN-CENELEC Management Centre or to any CEN
member.
This European Standard exists in three official versions (English, French, German). A version in any other language made by
translation under the responsibility of a CEN member into its own language and notified to the CEN-CENELEC Management
Centre has the same status as the official versions.

CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway,
Poland, Portugal, Republic of North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Türkiye and
United Kingdom.
EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION

EUROPÄISCHES KOMITEE FÜR NORMUNG

CEN-CENELEC Management Centre: Rue de la Science 23, B-1040 Brussels
© 2023 CEN All rights of exploitation in any form and by any means reserved Ref. No. EN ISO 10991:2023 E
worldwide for CEN national Members.

Contents Page
European foreword . 3

European foreword
This document (EN ISO 10991:2023) has been prepared by Technical Committee ISO/TC 48
"Laboratory equipment" in collaboration with Technical Committee CEN/TC 332 “Laboratory
equipment” the secretariat of which is held by DIN.
This European Standard shall be given the status of a national standard, either by publication of an
identical text or by endorsement, at the latest by March 2024, and conflicting national standards shall
be withdrawn at the latest by March 2024.
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. CEN shall not be held responsible for identifying any or all such patent rights.
This document supersedes EN ISO 10991:2009.
Any feedback and questions on this document should be directed to the users’ national standards
body/national committee. A complete listing of these bodies can be found on the CEN website.
According to the CEN-CENELEC Internal Regulations, the national standards organizations of the
following countries are bound to implement this European Standard: Austria, Belgium, Bulgaria,
Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland,
Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Republic of
North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Türkiye and the
United Kingdom.
Endorsement notice
The text of ISO 10991:2023 has been approved by CEN as EN ISO 10991:2023 without any modification.

INTERNATIONAL ISO
STANDARD 10991
Second edition
2023-09
Microfluidics — Vocabulary
Microfluidique — Vocabulaire
Reference number
ISO 10991:2023(E)
ISO 10991:2023(E)
COPYRIGHT PROTECTED DOCUMENT
© ISO 2023
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on
the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below
or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: +41 22 749 01 11
Email: copyright@iso.org
Website: www.iso.org
Published in Switzerland
ii
ISO 10991:2023(E)
Contents  Page
Foreword .iv
1  Scope .1
2  Normative references .1
3  Terms and definitions .1
3.1 General terms, relevant to microfluidics . 1
3.2 Terms related to microfluidic flow . 3
3.3 Terms related to microfluidic interfacing . 7
3.4 Terms related to modularity . 11
Bibliography .14
Index .15
iii
ISO 10991:2023(E)
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
bodies (ISO member bodies). The work of preparing International Standards is normally carried out
through ISO technical committees. Each member body interested in a subject for which a technical
committee has been established has the right to be represented on that committee. International
organizations, governmental and non-governmental, in liaison with ISO, also take part in the work.
ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters of
electrotechnical standardization.
The procedures used to develop this document and those intended for its further maintenance are
described in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the
different types of ISO documents should be noted. This document was drafted in accordance with the
editorial rules of the ISO/IEC Directives, Part 2 (see www.iso.org/directives).
ISO draws attention to the possibility that the implementation of this document may involve the use
of (a) patent(s). ISO takes no position concerning the evidence, validity or applicability of any claimed
patent rights in respect thereof. As of the date of publication of this document, ISO had not received
notice of (a) patent(s) which may be required to implement this document. However, implementers are
cautioned that this may not represent the latest information, which may be obtained from the patent
database available at www.iso.org/patents. ISO shall not be held responsible for identifying any or all
such patent rights.
Any trade name used in this document is information given for the convenience of users and does not
constitute an endorsement.
For an explanation of the voluntary nature of standards, the meaning of ISO specific terms and
expressions related to conformity assessment, as well as information about ISO's adherence to
the World Trade Organization (WTO) principles in the Technical Barriers to Trade (TBT), see
www.iso.org/iso/foreword.html.
This document was prepared by Technical Committee ISO/TC 48, Laboratory equipment, in collaboration
with the European Committee for Standardization (CEN) Technical Committee CEN/TC 332, Laboratory
equipment, in accordance with the Agreement on technical cooperation between ISO and CEN (Vienna
Agreement).
This second edition cancels and replaces the first edition (ISO 10991:2009), which has been technically
revised.
The main changes are as follows:
— title has been changed;
— several terms have been added to reflect the increased uptake of microfluidic technology.
Any feedback or questions on this document should be directed to the user’s national standards body. A
complete listing of these bodies can be found at www.iso.org/members.html.
iv
INTERNATIONAL STANDARD ISO 10991:2023(E)
Microfluidics — Vocabulary
1  Scope
This document provides terms and definitions for micro process engineering and microfluidics applied
in medical and veterinary diagnostics, chemistry, agriculture, pharmacy, biotechnology and the
agrifood industry, as well as other application areas.
2  Normative references
There are no normative references in this document.
3  Terms and definitions
ISO and IEC maintain terminology databases for use in standardization at the following addresses:
— ISO Online browsing platform: available at https:// www .iso .org/ obp
— IEC Electropedia: available at https:// www .electropedia .org/
3.1  General terms, relevant to microfluidics
3.1.1
biocompatibility
special quality of some materials allowing them to come into contact with biological materials without
changing the materials’ bioactivity
3.1.2
biomarker
biological molecule found in blood, other body fluids or tissues that is used to identify a disease or
monitor the progression of a disease
3.1.3
classification
method of sorting into categories
[SOURCE: ISO 5492:2008, 4.5]
3.1.4
end-user
person or persons who will ultimately be using the system (3.1.15) for its intended purpose
[SOURCE: ISO/IEC 19770-5:2015, 3.13, modified — Note 1 to entry has been removed.]
3.1.5
hydrophilic
characterised by affinity to water established by hydrogen bonding
3.1.6
hydrophobic
characterised by being repelled from a mass of water
ISO 10991:2023(E)
3.1.7
interested party
stakeholder
person or organization that can affect, be affected by, or perceive itself to be affected by a decision or
activity
[SOURCE: ISO 9000:2015, 3.2.3, modified — EXAMPLE and Note 1 to entry removed.]
3.1.8
interoperability
property permitting diverse systems (3.1.15) or components (3.4.7) to work together for a specified
purpose
[SOURCE: IEC 80001-1:2010, 2.11]
3.1.9
macroscale
scale of dimensions of 0,1 mm or greater
[SOURCE: SEMI MS003: 2015, 6.59]
3.1.10
microfluidics
manipulation of fluids that are confined in a small volume with at least one dimension smaller
than 1 mm
3.1.11
microscale
-3 -6
scale of dimensions between 0,1 × 10 m to 0,1 × 10 m
3.1.12
miniaturization
action of making things on a smaller scale
3.1.13
plug and play
ability to work perfectly when first used or connected, without reconfiguration or adjustment by the
user and thereby enabling automatic configuration
3.1.14
wettability
ability of a liquid to spread on a specific solid surface
[SOURCE: ISO 472:2013, 2.1607, modified — wording “(such as an adhesive)” has been deleted and
Note 1 to entry has been removed.]
3.1.15
system
group of interacting microfluidic, optical, mechanical or electrical components (3.4.7)
3.1.16
actuating resolution
lowest variation of a physical parameter that can be operated by a system (3.1.15)
3.1.17
capacity
flow rate through a pump at its designed conditions
ISO 10991:2023(E)
3.1.18
centrifugal microfluidics
subcategory of microfluidics (3.1.10) utilizing rotation
Note 1 to entry: The fluid flow is mainly controlled by centrifugal-, Euler- and Coriolis- forces.
3.1.19
closed system
system (3.1.15) that uses preloaded manufacturer-specific reagents only
3.1.20
digital microfluidics
subcategory of microfluidics (3.1.10) where discrete quantities of liquid are manipulated individually
over a surface
3.1.21
droplet microfluidics
subcategory of microfluidics (3.1.10) manipulating discrete quantities of liquid in a continuous flow
3.1.22
lab-on-a-chip
LoC
highly integrated, microfluidic system (3.1.15) providing analytical or diagnostic functions
3.1.23
open system
system (3.1.15) that requires an external supply of reagents
Note 1 to entry: Such an open system requires microfluidic connection(s).
3.1.24
resolution
smallest change in a quantity being measured that
...