ISO 6353-2:1983/Add 2:1986

Overview

ISO 6353-2:1983/Add 2:1986 is an important addendum to the international standard for Reagents for Chemical Analysis - Part 2: Specifications - First Series. Published by the International Organization for Standardization (ISO), this document provides detailed updates concerning the specification and testing of chemical reagents, particularly focusing on primary standard sodium carbonate (Na2CO3). The standard ensures accuracy and consistency in chemical analysis by defining precise methods and requirements for reagent purity and titration procedures.

This addendum supports laboratories and chemical manufacturers by promoting uniformity in reagent quality, a crucial factor in analytical chemistry and industrial applications involving chemical titrations and standardization processes.

Key Topics

• Sodium Carbonate Primary Standard (PS 30)
  The document specifies the quality and testing protocol for sodium carbonate used as a primary standard reagent, emphasizing:

  • An assay range of 99.95% to 100.05% by mass after drying at 285 °C.
  • Strict controls on the standard deviation of assay results (not exceeding 0.05%).
  • Compliance with the general reagent requirements of R 30.

• Titration and Standardization Techniques
  The standard details accurate titration methods for verifying the concentration of reagents:

  • Use of a 25 ml burette graduated in 0.05 ml intervals adhering to ISO 385/1 Class A accuracy.
  • Hydrochloric acid standard solution titration for assay confirmation.
  • Potentiometric measurement for precise endpoint determination, maintaining calibration at controlled temperatures (e.g., 20 ± 1 °C).

• Analytical Calculations and Statistical Methods
  The standard outlines specific formulas for calculating the assay value based on titration volumes and concentrations, along with procedures to compute mean values and standard deviations from multiple titrations to ensure statistical reliability of results.

• Preparation and Handling of Reagents

  • Instructions for drying sodium carbonate and storing it under desiccation before analysis.
  • Sample weighing precision to the nearest 0.0001 g to guarantee accuracy.

Applications

ISO 6353-2:1983/Add 2:1986 is widely applicable to laboratories and industries requiring stringent chemical reagent standards, such as:

• Analytical Chemistry Laboratories
  Ensures accurate preparation and standardization of reagents, critical for titrimetric analyses and quality control.

• Pharmaceutical and Biotechnology Industries
  Provides traceability and reproducibility in chemical assays essential for drug formulation and testing.

• Environmental and Food Testing
  Establishes reliable reagent specifications to maintain calibration integrity in environmental monitoring and food safety analysis.

• Chemical Manufacturing and Quality Assurance
  Supports manufacturers in producing reagents that meet international standards, facilitating global trade and compliance.

Related Standards

• ISO 385/1 – Specifies the requirements for burettes and volumetric glassware used in titration, ensuring measurement precision referenced in ISO 6353-2.

• ISO 6353-1 – Part 1 of the series covering general specifications for reagents for chemical analysis.

• ISO 6353 Series – Comprises various parts and addenda detailing reagent standards for different chemicals and purposes.

• GM 31.2 – General methods referenced within the titration procedures of this standard.

Keywords: ISO 6353-2, chemical reagents, sodium carbonate, primary standard, reagent specifications, chemical analysis, titration method, potentiometric titration, hydrochloric acid standard, analytical chemistry standard, reagent assay accuracy, volumetric analysis standards, ISO standards for chemical analysis.