SIST-TS CEN ISO/TS 19590:2024

SLOVENSKI STANDARD
01-november-2024
Nanotehnologija - Karakterizacija nanoobjektov z uporabo masne spektrometrije z
enim delcem v induktivno sklopljeni plazmi (ISO/TS 19590:2024)
Nanotechnologies - Characterization of nano-objects using single particle inductively
coupled plasma mass spectrometry (ISO/TS 19590:2024)
Nanotechnologien - Größenverteilung und Konzentration anorganischer Nanopartikel in
wässrigen Medien durch Massenspektrometrie an Einzelpartikeln mit induktiv
gekoppeltem Plasma (ISO/TS 19590:2024)
Nanotechnologies - Caractérisation des nano-objets par spectrométrie de masse à
plasma induit en mode particule unique (ISO/TS 19590:2024)
Ta slovenski standard je istoveten z: CEN ISO/TS 19590:2024
ICS:
07.120 Nanotehnologije Nanotechnologies
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.

CEN ISO/TS 19590
TECHNICAL SPECIFICATION
SPÉCIFICATION TECHNIQUE
August 2024
TECHNISCHE SPEZIFIKATION
ICS 07.120 Supersedes CEN ISO/TS 19590:2019
English Version
Nanotechnologies - Characterization of nano-objects using
single particle inductively coupled plasma mass
spectrometry (ISO/TS 19590:2024)
Nanotechnologies - Caractérisation des nano-objets par Nanotechnologien - Charakterisierung von
spectrométrie de masse à plasma induit en mode Nanoobjekten mit Hilfe der Massenspektrometrie mit
particule unique (ISO/TS 19590:2024) induktiv gekoppeltem Einzelpartikelplasma (ISO/TS
19590:2024)
This Technical Specification (CEN/TS) was approved by CEN on 12 August 2024 for provisional application.

The period of validity of this CEN/TS is limited initially to three years. After two years the members of CEN will be requested to
submit their comments, particularly on the question whether the CEN/TS can be converted into a European Standard.

CEN members are required to announce the existence of this CEN/TS in the same way as for an EN and to make the CEN/TS
available promptly at national level in an appropriate form. It is permissible to keep conflicting national standards in force (in
parallel to the CEN/TS) until the final decision about the possible conversion of the CEN/TS into an EN is reached.

CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway,
Poland, Portugal, Republic of North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Türkiye and
United Kingdom.
EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION

EUROPÄISCHES KOMITEE FÜR NORMUNG

CEN-CENELEC Management Centre: Rue de la Science 23, B-1040 Brussels
© 2024 CEN All rights of exploitation in any form and by any means reserved Ref. No. CEN ISO/TS 19590:2024 E
worldwide for CEN national Members.

Contents Page
European foreword . 3

European foreword
This document (CEN ISO/TS 19590:2024) has been prepared by Technical Committee ISO/TC 229
"Nanotechnologies" in collaboration with Technical Committee CEN/TC 352 “Nanotechnologies” the
secretariat of which is held by AFNOR.
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. CEN shall not be held responsible for identifying any or all such patent rights.
This document supersedes CEN ISO/TS 19590:2019.
Any feedback and questions on this document should be directed to the users’ national standards
body/national committee. A complete listing of these bodies can be found on the CEN website.
According to the CEN-CENELEC Internal Regulations, the national standards organizations of the
following countries are bound to announce this Technical Specification: Austria, Belgium, Bulgaria,
Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland,
Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Republic of
North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Türkiye and the
United Kingdom.
Endorsement notice
The text of ISO/TS 19590:2024 has been approved by CEN as CEN ISO/TS 19590:2024 without any
modification.
Technical
Specification
ISO/TS 19590
Second edition
Nanotechnologies —
2024-08
Characterization of nano-objects
using single particle inductively
coupled plasma mass spectrometry
Nanotechnologies — Caractérisation des nano-objets par
spectrométrie de masse à plasma induit en mode particule unique
Reference number
ISO/TS 19590:2024(en) © ISO 2024

ISO/TS 19590:2024(en)
© ISO 2024
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on
the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below
or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: +41 22 749 01 11
Email: copyright@iso.org
Website: www.iso.org
Published in Switzerland
ii
ISO/TS 19590:2024(en)
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Abbreviated terms . 3
5 Principles of operation . 4
5.1 Introduction to spICP-MS .4
5.2 Reference material dependent calibration methods .6
5.2.1 Particle frequency method .6
5.2.2 Particle size method .8
5.3 Reference material free calibration methods .9
5.3.1 Dynamic mass flow method .9
5.3.2 Microdroplet calibration method .11
5.4 Particle number concentration determination . 13
5.5 Particle mass and corresponding spherical equivalent diameter determination . .14
5.6 Dissolved element fraction .17
5.7 Multi-isotope and multi-elemental analysis .17
5.8 Data treatment .18
6 Method development . 19
6.1 Sample specification .19
6.2 Sample preparation .19
6.2.1 Aqueous suspensions and paste . 20
6.2.2 Non-aqueous suspensions and creams. 20
6.2.3 Powders .21
6.2.4 Larger pieces of solids .21
6.3 Selection of reference materials, quality control materials and representative test
materials .21
6.4 Optimization of ICP-MS operating conditions . 22
7 Qualification, performance criteria and measurement uncertainty .23
7.1 Applicability of spICP-MS . 23
7.2 System qualification and quality control . 23
7.3 Method performance criteria .24
7.3.1 Particle number concentration .24
7.3.2 Particle mass and equivalent spherical diameter .24
7.4 Method precision and measurement uncertainty . 25
8 General measurement procedure .25
9 Test report .26
9.1 Apparatus and measurement parameters . 26
9.2 Reporting test results . 26
Bibliography .27

iii
ISO/TS 19590:2024(en)
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
bodies (ISO member bodies). The work of preparing International Standards is normally carried out through
ISO technical committees. Each member body interested in a subject for which a technical committee
has been established has the right to be represented on that committee. International organizations,
governmental and non-governmental, in liaison with ISO, also take part in the work. ISO collaborates closely
with the International
...