ISO/FDIS 25585

FINAL DRAFT
International
Standard
ISO/TC 249/SC 1
Traditional Chinese medicine —
Secretariat: SAC
Notopterygium incisum and
Voting begins on:
Notopterygium franchetii rhizome
2026-10-08
and root
Voting terminates on:
2026-12-03
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MADE IN NATIONAL REGULATIONS.
Reference number
FINAL DRAFT
International
Standard
ISO/TC 249/SC 1
Traditional Chinese medicine —
Secretariat: SAC
Notopterygium incisum and
Voting begins on:
Notopterygium franchetii rhizome
and root
Voting terminates on:
© ISO 2026
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RECIPIENTS OF THIS DRAFT ARE INVITED TO SUBMIT,
WITH THEIR COMMENTS, NOTIFICATION OF ANY
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Reference number
ii
Contents Page
Foreword .v
Introduction .vi
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Descriptions . 2
5 Requirements and recommendations . 4
5.1 General characteristics .4
5.2 Macroscopic features .4
5.2.1 Rhizome and root of Notopterygium incisum .4
5.2.2 Rhizome and root of Notopterygium franchetii .4
5.3 Microscopic feature .5
5.4 Thin-layer chromatography (TLC) features .6
5.5 Characteristic fingerprint .6
5.6 Marker compounds .6
5.7 Essential oil.6
5.8 Ethanol-soluble extractive .6
5.9 Total ash .6
5.10 Acid-insoluble ash .6
5.11 Moisture .6
5.12 Foreign matter .6
5.13 Heavy metals .6
5.14 Pesticide residues .7
5.15 Sulfur dioxide . .7
5.16 Aflatoxins .7
6 Sampling . 7
7 Test methods . 7
7.1 Identification of macroscopic features .7
7.2 Identification of microscopic features .7
7.3 Identification of thin-layer chromatography .7
7.4 Determination of characteristic fingerprint .7
7.5 Determination of marker compounds .7
7.6 Determination of essential oil . .7
7.7 Determination of ethanol-soluble extractive .7
7.8 Determination of total ash .7
7.9 Determination of Acid-insoluble ash . .7
7.10 Determination of moisture .8
7.11 Determination of foreign matter .8
7.12 Determination of heavy metals .8
7.13 Determination of pesticide residues .8
7.14 Determination of sulfur dioxide .8
7.15 Determination of aflatoxins . .8
8 Test report . 8
9 Packaging, storage and transportation . 8
10 Marking and labelling . 9
Annex A (informative) Identification of thin-layer chromatogram .10
Annex B (informative) Determination of characteristic fingerprint .12
Annex C (informative) Determination of total content of notopterol and isoimperatorin .15
Annex D (informative) Reference of national and regional requirements . 17

iii
Annex E (informative) Grading information for Notopterygium rhizome and root . 19
Bibliography .20

iv
Foreword
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v
Introduction
The medicinal history of Notopterygium incisum and Notopterygium franchetii rhizome and root (abbreviated
as Notopterygium rhizome and root, Chinese Pinyin name Qiang Huo) dates back to over 2 000 years.
Notopterygium rhizome and root is used as a traditional herbal medicine in China, Japan, South Korea, the
United States, Netherlands, and other countries. It has played a role in various therapeutic effects, such as
an anti-inflammation, analgesic, antipyretic, antibacterial, antiviral, anti-arrhythmia, and anti-thrombotic,
intended for the treatment of common cold, headache, rheumatic pain, and rheumatoid arthritis, etc.
Origin plants of Notopterygium rhizome and root are Notopterygium incisum K. C. Ting ex H. T. Chang and N.
franchetii H. de Boiss. (Fam. Apiaceae) as recorded in several pharmacopeias, such as Chinese Pharmacopoeia,
Japanese Pharmacopoeia, Korean Pharmacopoeia, and European Pharmacopoeia. In addition, the Korean
Pharmacopoeia contains Ostericum koreanum rhizome and root for local use.
The establishment of an international standard for Notopterygium rhizome and root is necessary to
guarantee the clinical effectiveness, patient safety, and controllability in global commerce and trade.
As national implementation may differ, national standards bodies are invited to modify the values given in
5.6, 5.7, 5.9, 5.10 and 5.11 in their national standards. Examples of national and regional values are given in
Annex D. In addition, grading information of Notopterygium rhizome and root are given in Annex E.

vi
FINAL DRAFT International Standard ISO/FDIS 25585:2026(en)
Traditional Chinese medicine — Notopterygium incisum and
Notopterygium franchetii rhizome and root
1 Scope
This document specifies the quality and safety requirements of Notopterygium incisum and Notopterygium
franchetii rhizome and root (abbreviated as Notopterygium rhizome and root).
This document applies to Notopterygium rhizome and root that is sold and used as natural medicine in
international trade, including Chinese materia medica (whole medicinal materials) and decoction pieces
derived from this herb, excluding wild source herbs.
2 Normative references
The following documents are referred to in the text in such a way that some or all of their content constitutes
requirements of this document. For dated references, only the edition cited applies. For undated references,
the latest edition of the referenced document (including any amendments) applies.
ISO 16791, Health informatics — Requirements for international machine-readable coding of medicinal product
package identifiers
ISO 18664, Traditional Chinese Medicine — Determination of heavy metals in herbal medicines used in
Traditional Chinese Medicine
ISO/TS 21310, Traditional Chinese medicine — Microscopic examination of medicinal herbs
ISO 21371, Traditional Chinese medicine — Labelling requirements of products intended for oral or topical use
ISO 22217, Traditional Chinese medicine —Storage requirements for raw materials and decoction pieces
ISO 22258, Traditional Chinese medicine — Determination of pesticide residues in natural products by gas
chromatography
ISO 22283, Traditional Chinese medicine — Determination of aflatoxins in natural products by LC-FLD
ISO 22590, Traditional Chinese medicine — Determination of sulfur dioxide in natural products by titration
ISO 23723, Traditional Chinese medicine — General requirements for herbal raw material and materia medica
3 Terms and definitions
For the purposes of this document, the following terms and definitions apply.
ISO and IEC maintain terminological databases for use in standardization at the following addresses:
— IEC Electropedia: available at http:// www .electropedia .org/
— ISO Online browsing platform: available at http:// www .iso .org/ obp

3.1
Notopterygium rhizome and root, noun
dried rhizome and root of Notopterygium incisum K. C. Ting ex H. T. Chang and/or Notopterygium franchetii H.
de Boissieu (family Apiaceae) subject to primary processing (3.2), harvested in autumn or early spring when
the aerial part of the plant wither
Note 1 to entry: An admitted term for Notopterygium rhizome and root (3.1) is Notopterygium incisum and Notopterygium
franchetii rhizome and root.
Note 2 to entry: The Chinese Pinyin name for Notopterygium rhizome and root (3.1) is Qiang Huo.
Note 3 to entry: Notopterygium (3.1) rhizome and root crude drug is classified into multiple commercial specifications
by macroscopic characteristics, namely silkworm-form (3.3)Notopterygium rhizome (Canqiang), bamboo-form (3.5)
Notopterygium rhizome (Zhujieqiang), nodular-form (3.4)Notopterygium rhizome (Datouqiang), and strip-form  (3.6)
Notopterygium rhizome and root (Tiaoqiang). Materials with irregular morphology are designated as mixed goods.
3.2
primary processing
stage of the pre-treatment of natural materials during the collecting and harvesting process by which the
raw materials are transformed into medicinal materials
Note 1 to entry: The primary processing includes removing rootlet and clay and drying in the sun or in the oven
(usually below 60 °C).
[1]
[SOURCE: ISO 21300:2019 , 3.4, modified — Note 1 to entry has been added.]
3.3
silkworm-form Notopterygium rhizome, noun
rhizome of Notopterygium incisum (Apiaceae), a morphological subtype of Notopterygium rhizome and root
(3.1), characterized by a stout cylindrical shape, dense protruding nodes, rounded stem bases retained at
the apex, and an overall morphology resembling a silkworm
Note 1 to entry: The Chinese Pinyin name for silkworm-form Notopterygium rhizome (3.3) is Can Qiang.
3.4
nodular-form Notopterygium rhizome, noun
rhizome of Notopterygium incisum or Notopterygium franchetii (Apicaceae), a morphological subtype of
Notopterygium rhizome and root (3.1), characterized by irregular nodular swellings at junctions, multiple
stem scars at apex, and numerous thin roots trailing distally
Note 1 to entry: The Chinese Pinyin name for nodular-form Notopterygium rhizome (3.4) is Da Tou Qiang.
3.5
bamboo-form Notopterygium rhizome, noun
rhizome of Notopterygium incisum or Notopterygium franchetii (Apicaceae), a morphological subtype of
Notopterygium rhizome and root (3.1), characterized by elongated internodes, sparse nodes, and an overall
morphology resembling bamboo joints
Note 1 to entry: The Chinese Pinyin name for bamboo-form Notopterygium rhizome (3.5) is Zhu Jie Qiang.
3.6
strip-form Notopterygium rhizome and root, noun
root and rhizome of Notopterygium incisum or Notopterygium franchetii (Apiaceae), a morphological subtype
of Notopterygium rhizome and root (3.1), characterized by an elongated strip-like morphology with conical
ox-tail-shaped root (tapering to a tail-like tip) and bamboo-form Notopterygium rhizome (3.5)
Note 1 to entry: The Chinese Pinyin name for strip-form Notopterygium rhizome and root (3.6) is Tiao Qiang.
4 Descriptions
Notopterygium rhizome and root is t
...