ISO/TC 48/WG 4 - Liquid Handling Devices – Manual and Semi-Automatic

This document provides user guidance regarding the selection of piston-operated volumetric apparatus (POVA) (including exchangeable parts) and best practices for their use. This document also specifies requirements for user training and competence. Further, this document introduces performance tolerances and testing of POVA to ensure fitness for their intended use.

This document gives detailed information regarding the evaluation of uncertainty for the photometric reference measurement procedure specified in ISO 8655-8 and the photometric procedure specified in ISO 8655-7:2022, Annex B according to ISO/IEC Guide 98-3. This document also describes the determination of other uncertainty components related to the liquid delivery process of a piston-operated volumetric apparatus (POVA), e.g. repeatability and handling. Furthermore, it provides examples for the calculation and application of the uncertainty of the mean delivered volume and the uncertainty in use of a single delivered volume.

This document gives detailed information regarding the evaluation of uncertainty for the gravimetric reference measurement procedure specified in ISO 8655-6[1] and the gravimetric procedure specified in ISO 8655-7:2022[1], Annex A, according to the ISO/IEC Guide 98-3[16]. This document also includes the determination of other uncertainty components related to the liquid delivery process of a piston-operated volumetric apparatus (POVA), e.g. repeatability and handling. Furthermore, it provides examples for the calculation and application of the uncertainty of the mean delivered volume and the uncertainty in use of a single delivered volume.

This document specifies a gravimetric reference measurement procedure for the determination of volume of piston-operated volumetric apparatus (POVA). The procedure is applicable to complete systems comprising the basic apparatus and all parts selected for use with the apparatus, disposable or reusable, involved in the measurement by delivery (Ex) or contained (In).

This document specifies — metrological requirements, — maximum permissible errors, — requirements for marking and — information to be provided for users, for air-displacement (type A) and positive displacement (type D) single-channel and multi-channel pipettes, complete with their selected tip(s) and any other essential, consumable parts, designed to deliver the selected volume (Ex).

This document specifies general requirements for piston-operated volumetric apparatus (POVA). It is applicable to pipettes, burettes, dilutors, dispensers and manually operated precision laboratory syringes. It furthermore defines terms for the use of piston-operated volumetric apparatus and gives user recommendations. This document does not apply to medical products intended for use on humans, e.g. for medical syringes.

This document specifies alternative measurement procedures for the determination of volume of piston-operated volumetric apparatus. The procedures are applicable to complete systems comprising the basic apparatus and all parts selected for use with the apparatus, disposable or reusable, involved in the measurement by delivery process (Ex). Methods described in this document are suitable for various maximum nominal volumes of piston-operated volumetric apparatus. It is the responsibility of the user to select the appropriate method.

This document specifies — metrological requirements, — maximum permissible errors, — requirements for marking and — information to be provided for users, for dispensers. It is applicable to dispensers with nominal volumes from 1 μl up to 200 ml, designed to deliver their volume (Ex).

This document specifies the photometric reference measurement procedure for the determination of volume of piston-operated volumetric apparatus (POVA). The procedure is applicable to complete systems comprising the basic apparatus with a maximum nominal volume of 5 000 µl and all parts selected for use with the apparatus, disposable or reusable, involved in the measurement by delivery (Ex).

This document specifies — metrological requirements, — maximum permissible errors, — requirements for marking and — information to be provided for users, for manually operated precision laboratory syringes made of glass or glass and metal designed to deliver their selected volume (Ex). Manually operated precision laboratory syringes are instruments used for delivering liquids and gases. The barrel is typically made of glass and the plunger and the needle are typically made of metal.

This document specifies — metrological requirements, — maximum permissible errors, — requirements for marking and — information to be provided for users, for dilutors with a sample uptake capacity (In) from 5 μl to 1 ml and a diluent capacity (Ex) from 50 μl to 100 ml. They are designed to deliver the sample and diluent together in measured proportion and measured volume.

This document specifies — metrological requirements, — maximum permissible errors, — requirements for marking and — information to be provided for users, for burettes. This document is applicable to burettes with nominal volumes up to 100 ml, designed to deliver their specified volume (Ex).